Ferroptosis evaluation in Parkinson disease
General Information:
Level |
Master |
Title |
Ferroptosis evaluation in Parkinson disease |
Specialty |
Immunology |
Cover Page:
Outline:
CONTENANT ii
ABBREVIATION LIST. VIII
INTRODUCTION. 1
Chapitre 1 Literature review 2
1. Parkinson disease 2
1.1. Parkinson disorder 2
1.2. Epidemiology 2
1.3. Ethology 2
1.3.1. Genetic factors 2
1.3.2. Environmental factors 2
1.3.3. Behavioural factors 2
1.4. Symptoms 3
1.5. Diagnosis 3
1.6. Types of Parkinson 4
1.7.Physiopathology 5
1.7.1.Dopaminergic lesions 5
1.7.2.Non dopaminergic lesions 5
1.7.3.Lewy bodies 5
1.8.Immune system and neuro-inflammation in PD 5
1.8.1.Neuroinflammation 5
1.9. Treatments 6
1.9.1.Therapy affecting motor signs 6
1.9.2.Non-motor symptom treatments 6
1.9.3. Non-steroidal anti-inflammatory drugs 6
1.9.4.Anti-a synuclein immunotherapy 6
2.NECROINFLAMMATION AND FERROPTOSIS 7
2.1.Necroinflammation 7
2.1.1. Definition 7
2.1.2.Origin 7
2.2.Ferroptosis 7
•Iron accumulation
•Lipid peroxidation
Loss of antioxidant functions 8
CHAPITRE 2 MATERIAL AND METHODS 9
1.THE STUDIED POPULATION 9
1.1.Individual patient interview 9
1.2.Ethical considerations 9
2.THE SAMPLES 9
2.1. Sampling 9
2.2. Determination of ROS markers 9
2.3.Determination of antioxidants activities 10
2.4.Iron determination (BioSystems S.A. Costa Brava, 30. 08030 Barcelona (Spain)) 10
THE VALUES REPRESENT MEANS + ERROR STANDARD 10
CHAPITRE 3 RESULTS AND INTERPRETATION 11
1.ROS MARKERS 11
1.1.Lipids peroxidation hallmarks 11
1.1.1. MDA (plasmatic and erythrocytes) and conjugated diene 11
1.2.Proteins oxidation hallmarks 11
1.2.1. plasmatic and erythrocyte carbonyl protein 11
2.ANTIOXIDANTS MARKERS 12
2.1. Catalase activity in plasma and erythrocyte lysate 12
2.2. Vitamin C level 12
2.3.Albumin concentration 12
3.IRON CONCENTRATION 12
CHAPITRE 4 DISCUSSION 13
CHAPITRE 5 CONCLUSION 13
REFERENCES 13
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