Modifications H3K4Me3 au sein du monocyte infecté par SARS-COV-2
General Information:
Master |
Level |
Modifications H3K4Me3 au sein du monocyte infecté par SARS-COV-2 |
Title |
Immunologie |
Specialty |
Cover Page:
Outline:
Avant-propos
Introduction
1. Coronavirus (2019 -nCOV)
1.1 History and origin.
1.2 Characteristics of Coronavirus (2019-ncov)
1.2.1 SARS-CoV-2 Virus Structure and Integration
1.2.2 Pathogenesis of the 2019-nCoV
1.2.3 The ACE2 receptor.
1.2.4 Interaction between SARS-CoV-2 and ACE.
1.3 Epidemiology of the coronavirus (2019-ncov).
1.3.1 Pandemic SARS-CoV-2/COVID-19
1.4 Corona virus (2019-ncov) and vaccination Monocyte
2.1 Monocyte heterogeneity and function
2.2 Control of Monocyte Subset Production and Functional Programming.
2.3 Monocyte Subsets and Phenotypes.
3 Monocyte and Covid 19
3.1 Hyperinflammation in severe COVID-19.
4 Trained immunity/ monocytes.
4.1 WHEN TRAINED CELLS ENCOUNTER SARS-COV-2.
4.2 Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.
4.2.1 Epigenetic Regulation
4.3 Innate Immune Training Is Dependent on Histone Modification
5 Problematic and objective
5.1 Problematic.
5.2 Objective
5.3 Purpose
2 Chapter 2. Materials and methods
2.1 Preparation of PBMC
2.2 MOs isolation
2.3 Quantify the level of histone H3 lysine 4 methylation.
2.3.1 Procedure
Cell Wash.
3 Chapter 3. Results and discussion
4 Chapter 4.Conclusion
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